Molecular Signaling and Epigenetics

Cun-Yu Wang Lab
Photo of Dr. Cun-Yu Wang

Principal Investigator:

Cun-Yu Wang, D.D.S., Ph.D.

About

Cun-Yu Wang, DDS, PhD is the Associate Dean of Graduate Studies, the Dr. No-Hee Park Endowed Chair in Dentistry, and the Chair of the Division of Oral Biology and Medicine at the UCLA School of Dentistry. Dr. Wang is the first person to hold the Dr. No-Hee Park Endowed Chair in Dentistry.

Dr. Wang works in three major areas related to human health and medicine: 1) Molecular signaling, epigenetics and therapeutics of oral, head and neck Cancer; 2) Molecular regulation of oral and systemic inflammation and infection; and 3) Molecular and epigenetic control of adult stem cell properties, skeletal aging and craniofacial regeneration. He have made a landmark discovery on the regulation of cancer cell death by the transcription factor NF-κB, which was cited in one of ten important discoveries in 1996 by Science magazine. He has published over 150 peer-reviewed papers in the peer-reviewed journals, including Science, Cell, Cell Stem Cell, Cancer Cell, Nature Cell Biology, Nature Biotechnology, and Nature Medicine. He has won numerous awards, including the NIH MERIT Award and Distinguished Alumni Award of Peking University Health Science Center. He serves as an Honorary Editor-in-Chief of International Journal of Oral Science. He was elected to the National Academy of Medicine as a member in 2011 and to the Chinese Academy of Engineering as a foreign member in 2013.

Current Projects and Grants

  1. Molecular and genetic determinants of invasions in HNSCC
  2. PGC-1α regulates inflammation and bone loss in periodontitis through NF-κB
  3. Epigenetic regulation of orofacial bone homeostasis and aging by KDM4B
  4. Effects of Chinese Herbals on Anti-aging and Inflammation
  5. Molecular regulation of dental stem cell property

Publications

  • Chen D, Wang CY. Targeting cancer stem cells in squamous cell carcinoma. Precis Clin Med. 2019 Sep;2(3):152-165.
  • Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes Dev. 2020 Jan 1;34(1-2):72-86.
  • Chen D, Wu M, Li Y, Chang I, Yuan Q, Ekimyan-Salvo M, Deng P, Yu B, Yu Y, Dong J, Szymanski JM, Ramadoss S, Li J, Wang CY. Targeting BMI1+ Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma. Cell Stem Cell. 2
  • Yu B, Huo L, Liu Y, Deng P, Szymanski J, Li J, Luo X, Hong C, Lin J, Wang CY. PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. Cell Stem Cell. 2018 Aug 2;23(2):193-209.e5.
  • Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. RAP2 mediates mechanoresponses of the Hippo pathway. Na

Lab Members

Collaborators

List of collaborators within and outside of UCLA:

  • Guoping Fan (UCLA)
  • Reubin Kim (UCLA)
  • Bo Yu (UCLA)
  • Karen Lyson (UCLA)
  • Antonio Ribas (UCLA)
  • Chrisitine Hong (UCSF)
  • Kun-Liang Guan (UCSD)

List of Lab Members:

  • Bo Yu, Assistant Professor
  • Insoon Chang, Post-Doc
  • Peng Deng, Post-Doc
  • Mari Ekimyan Salvo, Lab Manager
  • Wuchang Zhang, Research Scientist
  • Lingfei Jia, Research Scientist
  • Jinkoo Kim, Research Scientist
  • Wei Liu, Post-Doc
  • Jingtao Li, Research Scientist
  • Xing Yin, Research Scientist
  • Jiongke Wang, Research Scientist
  • Hongchao Cao, Research Scientist
  • Luis Garcia, Student Worker
  • Yi-Ling Loo, Research Scientist
  • Ping Zhou, Post-Doc
  • Wenjie Tao, Research Scientist
  • Yilun Wang, Undergrad
  • Christopher Mederos, Undergrad

Opportunities

We have postdoctoral positions open for whom is interested in cancer stem cells, cancer immunotherapy and epigenetics.